ABSTRACT
ABSTRACT Purpose: To assess the relationship between pseudoexfoliation syndrome and incidence of complications and related clinical factors in patients undergoing cataract surgery. Methods: We conducted a retrospective cohort study of 503 of 551 patients who underwent phacoemulsification surgery over 2 years in a health care district in Northwest Spain. In total, 120 of 681 eyes undergoing the procedure had pseudoexfoliation syndrome. Data on the surgical procedure and associated complications were extracted from the medical record. Complications included any combination of posterior capsular rupture, vitreous loss, zonular dialysis, and nuclear or lens luxation. Results: We found a significant association between pseudoexfoliation syndrome and zonular dialysis (odds ratio [OR], 6.89; 95% CI, 2.27-20.93), intraoperative miosis (OR, 2.15; 95% CI, 1.10-4.22), and lens luxation >1.5 mm (OR, 9.49; 95% CI, 0.85-105.54). However, when adjusting for the overall risk of complications in pseudoexfoliation syndrome patients in consideration of myopia, use of anticoagulants or α-agonists, previous mydriasis, and anterior chamber length, the OR decreased to 1.02 (95% CI, 0.47-2.21) and was therefore not significant. Conclusion: Zonular dialysis and intraoperative miosis were intraoperative complications in cataract surgery patients with pseudoexfoliation syndrome when compared to controls.
RESUMO Objetivo: Avaliar a relação entre a síndrome de pseudoexfoliação e a prevalência de complicações e fatores clínicos relacionados em pacientes submetidos à cirurgia de catarata. Métodos: Foi realizado um estudo retrospectivo de coorte de 503 de 551 pacientes que se submeteram à cirurgia de facoemulsificação durante 2 anos em um distrito de saúde no noroeste da Espanha. No total, 120 dos 681 olhos submetidos ao procedimento apresentavam síndrome de pseudoexfoliação. Dados sobre o procedimento cirúrgico e complicações associadas foram obtidos dos prontuários médicos. As complicações incluíram qualquer combinação de ruptura da cápsula posterior, perda de humor vítreo, diálise zonular e luxação do núcleo ou do cristalino. Resultados: Encontramos uma associação significativa entre síndrome de pseudoexfoliação e diálise zonular (razão de probabilidade [RP]: 6,89; IC 95%, 2,27-20,93), a miose perioperatória (RP: 2,15; IC 95%, 1,10-4,22) e luxação do cristalino >1,5 mm (RP: 9,49; IC 95%, 0,85-105,54). Porém, ao ajustar para o risco global de complicações em pacientes com síndrome de pseudoexfolição em consideração à miopia, uso de anticoagulantes ou α-agonistas, midríase prévia e comprimento da câmara anterior, a RP diminuiu para 1,02 (IC 95%, 0,47-2,21) e não foi, portanto, significativo. Conclusão: A diálise zonular e a miose intraoperatória foram complicações intraoperatórias em pacientes submetidos à cirurgia de catarata com síndrome de pseudoexfoliação quando comparados aos controles.
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Cataract/complications , Exfoliation Syndrome/complications , Phacoemulsification/adverse effects , Intraoperative Complications/epidemiology , Postoperative Complications/epidemiology , Spain/epidemiology , Time Factors , Cataract/physiopathology , Cataract/epidemiology , Visual Acuity , Logistic Models , Prevalence , Retrospective Studies , Risk Factors , Follow-Up Studies , Exfoliation Syndrome/physiopathology , Exfoliation Syndrome/epidemiology , Statistics, NonparametricABSTRACT
La pseudoexfoliación es una alteración de la matriz extracelular fuertemente asociada a catarata y glaucoma secundario de ángulo abierto. Relacionada con la edad avanzada y más común en mujeres, es una enfermedad sistémica con típicas alteraciones en el ojo que hacen más difícil la cirugía, especialmente la debilidad zonular y la poca dilatación pupilar. Los pacientes con pseudoexfoliación operados de catarata, requieren un seguimiento posoperatorio más cuidadoso para detectar y tratar tempranamente las complicaciones posoperatorias como es la contracción capsular del caso que presentamos y que resolvió con tratamiento de Yag Láser en los bordes de la capsulorrexis(AU)
Pseudoexfoliation is an extracelular matrix alteration closely associated with cataract and secondary open angle glaucoma. Older age-related and more common in women, it is a systemic illness with typical alterations in the eye such as zonular weakness and little pupil dilation, which makes the surgery more difficult. The patients with pseudoexfoliation and caratact surgery require a more careful postoperative follow-up to early detect and to treat the postoperative complications such as the capsular contraction of the case reported in this paper, which was treated with Yag Laser in the capsulorhexis borders(AU)
Subject(s)
Humans , Female , Aged, 80 and over , Capsulorhexis/adverse effects , Cataract Extraction/methods , Exfoliation Syndrome/complications , Glaucoma, Open-Angle/therapy , Lasers, Solid-State/therapeutic useABSTRACT
Pseudoexfoliation syndrome (PES) is a common age-related fibrillopathy related to accumulation of pseudoexfoliation material (PEM) in certain places in the body, especially blood vessels. Erectile dysfunction (ED) is another condition related to vascular pathology and in this study it is aimed to identify the relationship between ED and PES.
Data of 92 patients were investigated. There were 34 patients in the PES group and 58 patients in the control group. Presence of diabetes, hypertension, smoking history, BMI, and serum levels of lipids and testosterone were recorded. The groups were compared for ED rates and severity. Also logistic regression analysis was performed to identify independent risk factors for development of ED.
Mean age of the population was 67.3. No significant difference was observed between the two groups regarding the presece of DM, HT, smoking, BMI and laboratory measurements. ED rate was significantly higher in the PES group (70.6% vs 48.3%, p=0.002). Also, severe ED rate was higher in the PES group (p=0.002). PES was detected as an independent risk factors for the development of ED.
ED is a possible consequence of PES. ED rate and severity is found to be higher in the PES group and PES is detected as an independent risk factor for development of ED. Patients with PES should be informed about development of ED and further prospective trials with objective measurements of penile blood flow should be conducted to verify the erectile status and penile blood fow in PES patients.
Subject(s)
Aged , Humans , Male , Middle Aged , Endothelium, Vascular , Erectile Dysfunction/etiology , Exfoliation Syndrome/complications , Vascular Diseases/complications , Age Factors , Body Mass Index , Cholesterol/blood , Diabetes Complications , Epidemiologic Methods , Endothelium, Vascular/physiopathology , Erectile Dysfunction/physiopathology , Exfoliation Syndrome/physiopathology , Hypertension/complications , Penis/blood supply , Risk Factors , Smoking/adverse effects , Triglycerides/blood , Vascular Diseases/physiopathologyABSTRACT
To assess the prevalence of pseudoexfoliation syndrome [PEX], and associated ophthalmic complications among Saudi patients. The prevalence of PEX and associated ocular co-morbidities were determined among the Saudi patients visiting the Primary Care Clinic of Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia, between January 2009 and January 2010. A total of 1967 patients were examined biomicoscopically by ophthalmologists to determine the presence of PEX and associated ocular complications. Sixty-nine of the 1967 examined patients [3.5%] showed the presence of PEX with no significant gender difference. There was an age dependent increase in the prevalence of PEX after the age of 50 years. Pseudoexfoliation syndrome was associated with higher intraocular pressure, cataract, and poor vision. There was no significant difference in the prevalence of PEX in male and female Saudi patients. Pseudoexfoliation syndrome is an age-related disorder, and its prevalence increases with age. Further larger population based studies are warranted to assess the prevalence of PEX and associated risk factors
Subject(s)
Humans , Male , Female , Prevalence , Exfoliation Syndrome/complicationsABSTRACT
El síndrome de pseudoexfoliación es un desorden sistémico de la matriz extracelular relacionado con la edad, que no solo causa glaucoma crónico de ángulo abierto y catarata, sino que también se relaciona con complicaciones intraoculares espontáneas y quirúrgicas. Las investigaciones recientes han permitido entender sus efectos en tejidos oculares al mejorar los criterios diagnósticos, aplicar nuevos tratamientos y desarrollar nuevas estrategias preventivas para disminuir las complicaciones quirúrgicas. Los nuevos conceptos de patología genética describen al síndrome de pseudoexfoliación como una microfibrilopatía que involucra al factor de crecimiento B-1, el estrés oxidativo y el daño a los mecanismos de protección celular. Se hace una valoración clínica y quirúrgica del glaucoma y la catarata en presencia de pseudoexfoliación.
Pseudoexfoliation syndrome is an age-related generalized fibrotic matrix disorder, which may not only cause chronic open angle glaucoma and cataract, but also a range of other serious spontaneous and surgical intraocular complications. Recent research studies have led to better understanding of effects of the pseudo exfoliation process on ocular tissues by refining diagnostic criteria, applying new therapeutic regimes, and by developing new preventive strategies to reduce surgical complications. The new pathogenetic concepts describe pseudoexfoliation syndrome as microfibrillopathy involving transforming growth factor-B1, oxidative stress, and impaired cellular protection mechanisms. A clinical and surgical evaluation of glaucoma and cataract in patients with pseudoexfoliation was presented in this article.
Subject(s)
Humans , Cataract/diagnosis , Glaucoma, Open-Angle/complications , Exfoliation Syndrome/complications , Exfoliation Syndrome/diagnosis , Exfoliation Syndrome/therapy , Lens Implantation, Intraocular/statistics & numerical dataABSTRACT
We report the surgical technique and outcome of planned posterior assisted levitation (P-PAL) in four cases of subluxated cataract. P-PAL was planned as the preferred approach in all cases. A spatula was inserted via the pars plana, the whole lens was lifted to the anterior chamber and then removed through a scleral tunnel incision. Anterior chamber intraocular lenses were implanted in all cases. All four eyes had severe subluxation of the crystalline lenses with marked phacodonesis. Two eyes had history of blunt trauma, and the other two eyes had severe pseudoexfoliation with spontaneous lens subluxation. Follow-up ranged from 1 to 2 years in three cases. The postoperative visual acuity was 20/80 or better. No intraoperative complications were observed. In conclusion, the P-PAL technique was successfully performed during cataract surgery in four eyes with severe subluxated cataracts. There were no complications over the long-term follow-up.
Subject(s)
Cataract/therapy , Cataract Extraction/methods , Cataract Extraction/mortality , Dialysis/methods , Exfoliation Syndrome/complications , Humans , Ophthalmologic Surgical Procedures/methods , Ophthalmologic Surgical Procedures/mortality , Patients , Treatment Outcome , Wounds, Nonpenetrating/complicationsABSTRACT
Presence of exfoliation syndrome (XFS) is associated with an increased risk of complications during cataract surgery. This risk is, in part, dependent on the severity of XFS. We describe a central bulge ("lenticonus") in the anterior lens capsule of some eyes with XFS. This finding is associated with very fragile zonules and a high risk for intraoperative zonular dialysis.